Job Description

Job Description

Job Description

At Lyterian Therapeutics, we are committed to developing medicines for patients in need by co-opting physiologically-relevant protein homeostatic mechanisms to regulate genetically-validated targets.

As an Associate Director, Computational Chemistry, you will apply computational chemistry methods to support drug discovery, optimization, and development within the chemistry team. You will collaborate with medicinal chemists and biologists to guide the optimization of drug candidates that induce protein degradation.

We look for teammates who are inspired by our mission and want to work in a collaborative, rigorous, and entrepreneurial environment. We seek candidates who are self-motivated, collaborative, proactive, and possess a strong desire to discover novel biology and new drugs. Efficient time management, excellent organizational and communication skills, and passion for high-quality, translational science are essential. 

• Lead Lyterian’s CADD-related research such as virtual screening, hit identification and structure-based design during lead optimization of small molecules
• Work with medicinal chemists and biologists to guide the optimization of drug candidates
• Use machine-learning (ML) to build in silica models to predict DMPK properties
• Perform and automate high throughput molecular dynamics simulations to predict protein function and protein-ligand binding
• Scientific programming to enhance our scientific methods and capabilities
• Apply established tools but also design new methods/tools to answer specific questions
• Develop and contribute to company's intellectual property (IP) domain by way of patents and/or publications
• Stay up-to-date with emerging scientific literature
• Collaborate and communicate across a diverse scientific team to successfully progress Lyterian goals

• PhD in computational chemistry or related discipline with 7-15 years of industrial/postdoctoral experience in drug discovery
• Expertise in computer aided drug design (CADD) /structure- and ligand-based design
• Practical, working experience with computational chemistry software from companies such as Dotmatics, Schrodinger, Molecular Operating Enviroment (MOE), OpenEye, and Gaussian
• Experience in collaborating with other functional team members such as chemists and biologists
• Experience in QSAR, QSPR, conformational analysis and as much as the following areas: molecular mechanics and dynamics, quantum mechanics, statistical design of experiments (DoE), multiparameter optimization, and/or Artificial Intelligence/Machine Learning (AI/ML)
• Computer skills including programming experience with languages such as perl, python, or C++, preferably in a UNIX environment is a plus
• Expertise in algorithms for cheminformatics/database applications, with understanding of software development strategy and practice is a plus
• A solid understanding of experimental assay methods and technology used to identify and quantify protein-ligand interactions, a working knowledge of in vitro/in vivo DMPK principles is a plus
• Initiative and boldness to dive into a fast-paced new startup

The expected base salary range for the Associate Director level is $195,000 - $211,000. We encourage candidates of all levels to apply as there is often flexibility on job title and responsibilities. Compensation will be based on a variety of factors, including experience, qualifications, internal equity and location. Lyterian offers a competitive employment package that includes an annual bonus, significant equity, and a generous benefits package including comprehensive health, dental, and vision insurance for our employees and their families, plus a 401K match.

At Lyterian, we believe that a diverse, open, and inclusive environment and culture is key to our success. We will not be influenced in recruiting, hiring, promoting or any other employment practices by race, color, citizenship status, national origin, ancestry, sex, sexual orientation, gender identity/expression, age, religion, physical or mental disability, medical or genetic condition, marital status, veteran status, or any other characteristics protected under applicable federal, state and local laws. Lyterian will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable laws.

Note to External Recruiters: Submission of unsolicited resumes prior to an agreement set in place does not create any implied obligation.

We may use artificial intelligence (AI) tools to support parts of the hiring process, such as reviewing applications, analyzing resumes, or assessing responses. These tools assist our recruitment team but do not replace human judgment. Final hiring decisions are ultimately made by humans. If you would like more information about how your data is processed, please contact us.

Job Tags

Similar Jobs